Books and reviews describing the SPL Technology

van Gaal, E. V. B., Hennink, W. E., Crommelin, D. J. A., and Mastrobattista, E. 2006. Plasmid engineering for controlled and sustained gene expression for nonviral gene therapy. Pharmaceutical Research 23:1053-1074.

Koebmann, B., Solem, C., and Jensen, P. R. 2006. Tunable promoters for systems biology: Applied to prokaryotic model systems. In Understanding and Exploiting Systems Biology in Biomedicine and Bioprocesses, 2^nd edition, (Cánovas, M., Iborra, J. L., and Manjón, A (eds.), Fundación CajaMurcia, Murcia, Spain, 2006, 299-314 .

Hammer, K., Mijakovic, I. , and Jensen, P. R. 2006. Synthetic promoter libraries-tuning of gene expression. Trends Biotechnol. 24:53-55.

Mijakovic, I. , Petranovic, D., and Jensen, P. R. 2005. Tunable promoters in systems biology. Curr. Opin. Biotechnol. 16:329-335.

Glick, B. R., and Pasternak, J. J. 2003. Chapter 6: Manipulation of gene expression in prokaryotes. In Molecular Biotechnology, 3^rd edition. ASM Press, Washington D. C., USA..

Kleerebezem. M., and Hugenholtz, J. 2003. Metabolic pathway engineering in lactic acid bacteria. Curr. Opin. Biotech. 14:232-237.

Nielsen, J. 2001. Metabolic engineering. Appl. Microbiol. Biotechnol. 55:263-283.

Keasling, J. D. 1999. Gene-expression tools for the metabolic engineering of bacteria. Trends Biotech. 17:452-460.

de Vos, W. M. 1999. Gene expression systems for lactic acid bacteria. Curr. Opin. Microbial. 2:289-295.

Papers describing the SPL Technology

Rud, I. , Jensen, P. R., Naterstad, K., and Axelsson, L. 2006. A synthetic promoter library for constitutive gene expression in Lactobacillus plantarum. Microbiology 152:1011-1019.

Solem, C., and Jensen, P. R. 2002. Modulation of gene expression made easy. Appl Environ Microbiol. 68:2397-2403.

Tornøe, J., Kusk, P., Johansen, T.E., and Jensen, P. R. 2002. Generation of a Synthetic Mammalian Promoter Library by modification of sequences spacing transcription factor binding sites. Gene, 297:21-32 .

Andersen, H. W., Schürmann, R., Madsen, K., Pedersen, M. B., Købmann, B. J., Piskur, J., Hammer, K., and Jensen, P. R. 1998. Synthetic promoters for experimental control analysis. In Proceedings of the 8^th International Meeting on BioThermoKinetics: BioThermoKinetics In the Post Genomic Era (Larsson, C., Påhlman, I., and Gustafsson, L. eds.), Chalmers Reproservice, Göteborg, Sweden, pp. 11-17.

Jensen, P. R., and Hammer, K. 1998. Artificial promoters for metabolic optimization. Biotechnol Bioeng. 58:191-195. Review

Jensen, P. R., and Hammer, K. 1998. The sequence of spacers between the consensus sequences modulates the strength of prokaryotic promoters. Appl. Environ. Microbiol. 64:82-87.

Jensen, P.R. and Hammer, K. 1998. Artificial promoter libraries for selected organisms and promoters derived from such libraries. International Publication Number, WO 98/07846

Papers applying the SPL Technology

Koebmann, B., Solem, C. , and Jensen, P. R. 2005. Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis. FEBS Journal FEBS 272:2292-2303.

Solem, C., Koebmann, B. J., and Jensen, P. R. 2003. Glyceraldehyde-3-phosphate dehydrogenase has no control over glycolytic flux in Lactococcus lactis MG1363. J. Bacteriol. 185:1564-1571.

Jeppsson, M., Johansson, B., Jensen, P. R., Hahn-Hägerdal, B., and Gorwa-Grauslund, M.F. 2003. The level of glucose-6-phosphate dehydrogenase activity strongly influences xylose fermentation and inhibitor sensitivity in recombinant Saccharomyces cerevisiae strains. Yeast 20:1263-1275.

K oebmann, B. J., Andersen, H. W., Solem, C., and Jensen, P. R. 2002. Experimental determination of control of glycolysis in Lactococcus lactis. Antonie van Leeuwenhoek 82:237-248. Review.

Koebmann, B. J., Westerhoff, H. V., Snoep, J. L., Solem, C., Pedersen, M. B., Nilsson, D., Michelsen, O., and Jensen, P. R. 2002. The extent to which ATP demand controls the glycolytic flux depends strongly on the organism and conditions for growth. Mol. Biol. Rep. 29:41-45.

Koebmann, B. J., Solem, C., Pedersen, M. B., Nilsson, D., and Jensen, P. R. 2002. Expression of genes encoding F₁-ATPase results in uncoupling of glycolysis from biomass production in Lactococcus lactis. Appl. Environ. Microbiol. 68:4274-4282.

Koebmann, B. J., Westerhoff, H.V., Snoep, J. L., Nilsson, D., and Jensen, P. R. 2002. The glycolytic flux in Escherichia coli is controlled by the demand for ATP. J. Bacteriol. 184:3909-3916.

Andersen, H. W., Pedersen, M. B., Hammer, K., and Jensen, P. R. 2001. Lactate dehydrogenase has no control on lactate production but has a strong negative control on formate production in Lactococcus lactis. Eur J Biochem. 268:6379-6389.

Andersen, H. W., Solem, C., Hammer, K., and Jensen, P. R. 2001. Twofold reduction of phosphofructokinase activity in Lactococcus lactis results in strong decreases in growth rate and in glycolytic flux. J Bacteriol. 183:3458-3467.

Koebmann, B. J., Pedersen, M. B., Nilsson, D., and Jensen, P. R. 2000. Is the glycolytic flux in Lactococcus lactis controlled by glycolysis itself? In Proceedings of the 9^th International Meeting on BioThermokinetics (1998): Animating the Cellular Map (J.-H. Hofmeyr, J. M. Rohwer, and J. L. Snoep (eds.)), Stellenbosch University Press, Stellenbosch, South Africa, pp. 299-306.

Koebmann, B. J., Nilsson, D., Snoep, J. L., Westerhoff, H. V., and Jensen, P. R. 1998. The glycolytic flux in E. coli appears to be controlled by the demand for ATP, p. 205-210. In Proceedings of the 8^th International Meeting on BioThermokinetics: BioThermoKinetics In The Post Genomic Era. (C. Larsson, I.-L. Påhlman, and L. Gustafsson (eds.)), Chalmers Reproservice, Göteborg, Sweden, pp. 205-210.